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Graduating from Osaka College of Design, Nishii was an animator previously affiliated with Studio Cockpit before working freelance. She is noted to be an avid fan of the Saint Seiya series, and is in charge of character design for Netflix's upcoming Saint Seiya: Knights of the Zodiac. Other series she's worked on as chief animation director include Fushigiboshi no Futago Hime, Penguindrum, Servant × Service and Haikara-san ga Tōru.
Nishii and Mitsuko Baba are often cited as having similar styles to Yoshihiko Umakoshi,[2] the three of them influenced by the works of Shingo Araki.[3]
Nishii also draws dōjinshi, most notably her original series, "Crown of Uroboros," which she sells annually at Comiket within her BBM / BKM circle.[3]