Aimoto was a former assistant of Akira Amano, creator of the series Katekyo Hitman Reborn!. She won the 33rd "Jump Twelve Newcomer Manga Award" (judged by Tsugumi Ohba) for Hanasaka Hime in December 2005. The same work was published in the 2006 Summer issue of Akamaru Jump, marking her debut.
Her one-shot MUDDY was first published in Jump the REVOLUTION! 2006. It was then published again in the 36th and 37th combined issue of Weekly Shonen Jump in 2007 as an entry in the 3rd Gold Future Cup. MUDDY ended up getting serialized in Weekly Shonen Jump from the 3rd to the 16th issue in 2008.
Hokenshitsu no Shinigami was her first most successful manga, serialized from the 41st issue of Weekly Shonen Jump in 2009 to the 29th issue in 2011.
Kemono Jihen is her current ongoing manga, which has been serialized since the January 2017 issue of Jump SQ. It received an anime adaptation which aired from January to March 2021.
In 2007, Aimoto stated that her favorite manga are Dragon Ball, JoJo's Bizarre Adventure, and Level E. She is a fan of video games, especially the Megami Tensei series. Jolyne Cujoh is her most liked JoJo.
On December 18, 2021, Aimoto received multiple death threats from Japanese, Chinese, Korean and English users online after posting preview pictures of her Jolyne one-shot on Twitter. The previews were posted to thank Hirohiko Araki and the editorial staff at Ultra Jump.