The Locacaca Organization is the tentatively-named mysterious, secret smuggling and research operation for the Locacaca fruit, with almost all of its known members being Rock Humans. The group's members, all of whom are Stand Users, serve as the primary antagonistic force of JoJolion.
The mastermind of the organization is Tooru, under the guise of Satoru Akefu, the head doctor of TG University Hospital. It is a covert group whose main goals include gaining the power of the New Locacaca's equivalent exchange and to secretly obtain and sell Locacaca fruits for wealth and power.
The organization is largely secretive and not much is known about its formation or history. In 1941, Tooru was spotted by Lucy Steel, a Speedwagon Foundation member investigating a new species of plant in Morioh, putting Locacaca plants in a pot before disappearing. In 2009, Damo's smuggling cartel began utilizing the Higashikata Fruit Parlor's cargo shipments on the vessel where Yoshikage Kira was employed. An unspecified number of years before 2011, four of its members joined the staff of T.G. University Hospital as doctors. Eventually, the group's mastermind would take over as Head Doctor.
The Damokan Group (ダモカン達 Damokantachi), led by Tamaki Damo, is primarily interested in smuggling Locacaca fruits. Working under Damo are Yotsuyu Yagiyama, Aisho Dainenjiyama, and the A. Phex Brothers. Jobin Higashikata serves as a business partner who used his family's business to launder money for Damo. The group's primary goals are monetary, wishing to market the Locacaca fruit to sick or injured clients willing to pay a high price for an opportunity to recover. Spikes or bulbs similar to those found on the Locacaca fruits themselves seem to be a recurring design element among those involved in the smuggling operation.
The organization secretly imports Locacaca fruits from New Guinea with the help of Jobin, who transports the fruits in and out of Japan as shipments from and to the Higashikata Fruit Company. In Japan, the fruits are transported in various ways and between members of the organization, until they are sold to wealthy clients afflicted in normally untreatable ways. The Locacaca's miraculous properties allows it to heal anything, thus it is highly sought after by whoever knows of its existence. Each fruit is sold at 200,000,000 yen by the group. During the transaction, the clients are required to be alone and pay in cash.
The organization seeks to preserve the secret of the Locacaca to themselves, and thus restricts its customer base to a few wealthy people. In order to prevent thefts, each fruit tree is weighed before and after each trade. When someone discovers the Locacaca, the organization tracks down the culprit with the full intention of killing them. After they robbed branches from the organization, Tamaki Damo goes after Yoshikage Kira and Josefumi Kujo and almost kills both. However, extraordinary circumstances leads to Kira and Josefumi escaping, resulting in the birth of Josuke Higashikata. Josuke's inquiry about his past leads to fights between him, Yasuho Hirose, Norisuke Higashikata IV and Tsurugi Higashikata against Yotsuyu, Aisho and the A.Phex Brothers. Damo is finally forced to confront the Higashikata family alone and is killed by Hato Higashikata and Josuke's concerted efforts.
Jobin eventually becomes the last remaining member of Damo's underground trade operation. Although he clearly shows signs of distress over Damo's death, he continues the former's hunt for the stolen branches for his own covert motivations. Rai Mamezuku later reveals that although he heard news of Damo's death, Damo himself isn't the only enemy. There are others that have slipped into society unnoticed and won't stop until they have the Locacaca in their possession. As such, this new threat obtains info on Rai's existence and pursues him, leading to Josuke and Yasuho having to battle the Rock Humans Urban Guerrilla and Doremifasolati Do to protect Rai.
Urban Guerrilla says that he allowed Damo and his men to roam free. However, he looks down on them as they used the Locacaca for their lust to make money, referring to them as nothing more than drug dealers.
According to Holy Kira, the members of this group were likely unaware of their superiors' roles as hospital staff.
T.G. University Hospital Research Team
The researchers of the organization work in the medical field whose interest in the Locacaca fruit seem to stem from a desire to benefit the Rock Human race. Members of the organization are extremely knowledgeable in the nature of the Locacaca. Their objective is to secure the New Locacaca for the benefit of at the very least its members, and at most the entire Rock Human race at large.
The research team consists of Satoru Akefu (secretly Tooru and his Stand, Wonder of U, under the guise of the Head Doctor), Poor Tom, Wu Tomoki, Urban Guerrilla and his pet Doremifasolati Do. Aside from Solati Do who serves as a vehicle for Urban Guerrilla, they are all doctors employed at TG University Hospital. They cultivate Locacaca to treat wealthy patients.
After Holy Joestar-Kira failed in her research of the Locacaca, Satoru and his group of researchers take over her laboratory in the back of the obstetrics examination room to cultivate several fruits. This would eventually lead to the development of an experimental regenerative medicine called Locacaca 6251.
Holy would later reveal the cause of her condition, being experimented on by the Head Doctor and his research team with the Locacaca 6251, causing overlapping events throughout JoJolion to occur.
The research group first encounters Josuke Higashikata on Mount Hanarero, where Urban Guerilla and Doremifasolati Do pursue Josuke, Yasuho Hirose, and the newly discovered plant appraiser, Rai Mamezuku. The doctor and his pet are both destroyed by the combined efforts of Josuke and Rai. However, before their deaths, Josuke deduces that the group's "human" identities are that of doctors, much to the shock of Urban Guerilla.
The group sought out Jobin Higashikata who briefly allies with Poor Tom. However, this alliance is not mutual, as Poor Tom gives limited information about his intentions and tricks Jobin into bringing a particularly dangerous automatic Stand onto his property. Jobin later betrays the group, taking the grafted branch for himself. The organization does not hesitate to kill off anybody that it thinks would pose a threat to its operation, including its own members. One of them kills Poor Tom when he fails in his mission to retrieve the grafted branch.
The group loses yet another member during an encounter with Yasuho Hirose and Mitsuba Higashikata, the latter of which had been administered pure Locacaca by Wu Tomoki in a series of beauty treatments. Wu attacks Yasuho using his Stand ability when she follows Mitsuba into his office. Upon realizing that she had experience several equivalent exchanges, as well as revealing to Yasuho that she was pregnant, Mitsuba becomes enraged at the doctor and uses her own ability to fight back. Wu eventually meets his end at the hands of Josuke, who covers his fragmented body with medicinal cement and causes him to suffocate.
After the death of Wu, the head doctor himself, Satoru Akefu, encounters the organization's opposition multiple times. The first of these encounters comes the next day, when Josuke, Yasuho, and Rai attempt to pursue him. However, Satoru's powerful ability to influence the path of objects (as well as the damage done by their collisions with individuals) proves to be too overwhelming for the group, and Satoru is able to evade them by getting onto a bus. Within the next few days, Akefu's Stand ability terrorizes both Josuke's group as well as other members of the Higashikata family, including Mitsuba. On the same day that Satoru gives a lecture on the use of the newly-developed Locacaca 6251, Josuke manages to enter TG University Hospital and, after healing his wounds with the drug, decides to pursue the Locacaca itself instead of Satoru in order to avoid activating the head doctor's Stand. The remaining member of the organisation is Satoru Akefu the head doctor, in reality a disguised Stand controlled by Tooru.
Jobin Higashikata hides the New Locacaca branch in his house, and Tooru sends Wonder of U to spy on the house and watch the family. Tooru also lays low while Wonder of U deals with Josuke Higashikata and Rai Mamezuku during the time period before the harvest. Tooru also tries to rekindle his relationship with Yasuho Hirose although he still focus on the Locacaca. Wonder of U automatically attacks and causes calamities against whoever wants to pursue him at the time.
During the day of the harvest, after a speech that Satoru Akefu makes about the hospital's new medicine the Locacaca 6251, Tooru has to face a two-pronged operation. His Stand confronts both the Higashikata Family at the Higashikata House, and Josuke Higashikata and Rai Mamezuku at the TG University Hospital, as well as Kei Nijimura. Tooru comes to the Higashikata House after Yasuho calls for help and he confirms that the fruit is at the Higashikatas. Tooru observes as all of his enemies get steadily eliminated through calamities, but then, Josuke unlocks a Stand power that can bypass his own: Soft & Wet: Go Beyond. Creating invisible and partially intangible bubbles, Josuke sends through a phone the bubbles right at Tooru which is heavily wounded. In his desperation, Tooru eats the last Locacaca fruit and tries to perform an equivalent exchange with Yasuho. However, Kaato Higashikata comes out and drops Tsurugi on him. The equivalent exchange goes wrong for Tooru, who dies, turning to dust.