Bucciarati makes his video game debut in GioGio's Bizarre Adventure as both a boss and a playable character. He is voiced by Takahiro Sakurai.
Bucciarati is the first enemy the player must face, appearing as an enemy in Chapters 1-1 and 1-2. As Chapter 1-1 mostly consists of a tutorial, Bucciarati has only half the health of a regular enemy. In Chapter 1-2, he first attempts to evade Giorno through the use of his zippers: at one of four places in the stage, Bucciarati can create a zipper and teleport to any of the other three. If he is dealt enough damage, he attempts to hide inside one of four civilians, requiring the player to find him in order to beat him. When he is fought directly as an enemy, his attack pattern primarily utilizes "My skills make you shiver, no?" and Stand Shoot attacks.
Although most of his moves are shared as a boss and a playable character, his zipper teleportation in Chapter 1-2 is exclusive to that stage. However, Bucciarati gains some new moves as a playable character: in Stand Mode, Bucciarati can cover large distances via a closing zipper, as well as temporarily disappear by traveling underground. During Chapter 11-2, the player plays as Bucciarati's soul in Diavolo's body; this unusual situation has no effect on his moveset.
- Another Story Mode: Chapters 2-1, 3-1, 4-3, 8-1, 10-1, 10-2, 11-3