Eyes of Heaven/Caesar Anthonio Zeppeli

Caesar was one of the first characters confirmed for the game, alongside Joseph, Jotaro, Kakyoin, Diego, and Stroheim. Since the game recycles several animations and copies a large portion of the move set from All-Star Battle, his gameplay remains mostly the same: Utilizing his bubbles in an almost exclusively-ranged play style.

As a Ripple user, Caesar has a Ripple Gauge that determines the strength of his attacks. Filling up the gauge will automatically empower his Normal and Powerful Attacks, and enhance/alter the properties of all his skills. It will also shorten the cooldown time on said skills. Using skills will drain a portion of the Ripple Gauge until there's an insufficient amount to use.

Moveset

 * Style Action - Ripple Breathing: Caesar performs a pose and Ripple Breathes, filling up the Ripple Gauge. He cannot move and is vulnerable to attacks while doing so.
 * Bubble Lens: Caesar summons a Bubble Cutter, but does not launch it at opponents, instead of leaving it suspended as a trap. The Cutter will reflect solar rays in the form of lasers at opponents that get too close before popping. If Ripple-enhanced, the skill will execute quicker and Caesar will summon two Cutters.
 * Bubble Cutter/Bubble Cutter Gliding: The attack unleashed is dependent on whether or not the activating button is held. If pressed Caesar summons five disc-shaped bubbles that he sends at an opponent with very slight homing capabilities. If held, the attack is similar to Bubble Cutter, except Caesar launches the projectiles at a low angle, and has better homing capabilities than Bubble Cutter. If Ripple-enhanced, Caesar will summon seven Cutters for both attacks.
 * Bubble Barrier: Caesar leaps into the air and summons a large unblockable Ripple Bubble, immobilizing opponent caught and shocking them with Ripple surges before exploding. If Ripple-enhanced, the damage and range of the bubble is increased and it gains some homing capabilities.
 * EX - Bubble Cutter/Bubble Cutter Gliding: Caesar recovers faster from both attacks, and both attacks have increased homing capabilities and remain for much longer at the cost of some speed.
 * EX - Bubble Barrier: Caesar gains invincibility until the bubble is unleashed.

Dual Heat Attacks

 * Solo - Burn black!: It works the same as the one from All-Star Battle, though Caesar does not explain how the lenses reflect light due to the animation being sped up.
 * With Joseph - Dual Ripple!: The two start off by attacking the opponent from opposite sides with an array of Ripple-infused bubbles from Caesar and a series of Ripple-charged punches and kicks from Joseph, before Joseph invites Caesar to initiate the Positive/Negative Overdrive they used on Suzi Q to save her from Esidisi's control, attacking the enemy from both sides with said move and shocking them with extreme power.

JoJolities

 * Control them both inside your body at the same time!: Caesar must completely fill his Ripple Gauge. (200 Points)
 * Gonna beat your ass back to the boonies!: Caesar must connect "Bubble Barrier". (200 Points)
 * Right now, my mind is back in the slums!: Caesar must perform a combo with at least 30 hits. Landing either of his DHAs will automatically achieve this. (300 Points)
 * Some of my bubbles can cleave the wind itself...: Caesar must connect Ripple-enhanced "Bubble Cutter" 10 times. (500 Points)
 * Your defeat will be cold and cruel!: Caesar must Retire an opponent with a Dual Heat Attack. (800 Points)

Story Mode
In the game's Story Mode, Caesar is encountered by Jotaro and Joseph along with his younger counter training at Air Supplena Island with the Ripple. Initially meeting the two with mistrust, Caesar and the others are soon attacked by Lisa Lisa and Rudol von Stroheim, who are affected by a strange phenomenon that Jotaro and Joseph encountered as with many others throughout their travels through time.

After defeating the two, Lisa Lisa is left unconscious, while Stroheim escapes. While Caesar took his master inside to rest, but not before she's presented a Corpse Part to heal her affliction, the other three are soon attacked by Hol Horse, another one of DIO's assassins.

In the Story Mode's credits, Caesar is shown fighting Esidisi and Wamuu alongside Joseph. It is unknown how his survival affected Parts 3 through 6.

Miscellaneous
If Caesar is paired with Joseph and falls in battle before him, a special animation will play where they recreate the scene involving Caesar's final words and creation of the blood bubble (hommage of Chapter 92 or Episode 20, which pops in an anti-climactic fashion shortly after conception), along with Joseph's iconic "CAESAR!!!" scream as tears stream down his face.

Unlike the previous game, his main color scheme is now based on his anime appearance.

Tournament
He is paired with Shigekiyo Yangu in the Eyes of Heaven tournament but was eliminated in the preliminaries by Joseph and Dio Brando.